After the tremendous popular success of the Fant?mas novels, both of the major French film studios — Pathé and Gaumont — vied for the rights to produce films based on the series. Gaumont won, and from April 1913 to May 1914 Louis Feuillade directed five Fant?mas films which critic David Thomson has described as "the first great movie experience."
Sometime in the near future, paraplegic prison inmate Matt Mills meets "The Board" of Satoshi-Telefair Industries, who thank him for joining the Program. Under pressure and with a promise to make him walk again, Mills agrees to volunteer. He is injected with a synthetic nanomaterial and suffocated, only to wake up with restored use of his legs, yet alone in a steel cell in the first spoke of an experimental apparatus - The Wheel. A series of assailants inflict a multitude of damage to Mills' body and torment his mind, yet the synthetic nanomaterial not only restores his damaged organs, it re-engineers his strength. The experiment might be designed to kill, but Mills is determined to survive - and get back to his daughter before The Board finds her first.